Cross-phenotype meta-analysis reveals large-scale trans-eQTLs mediating patterns of transcriptional co-regulation
نویسندگان
چکیده
1 Department of Neurology, Yale University School of Medicine, New Haven CT 06520 2 Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142 3 Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115 4 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115 5 Harvard Medical School, Boston, MA 02115 6 Department of Computer Science, Yale University, New Haven CT 06510 7 Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114 8 Department of Pharmacology and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104 9 Department of Genetics, Yale University School of Medicine, New Haven CT 06520
منابع مشابه
Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation.
Efforts to decipher the causal relationships between differences in gene regulation and corresponding differences in phenotype have been stymied by several basic technical challenges. Although detecting local, cis-eQTLs is now routine, trans-eQTLs, which are distant from the genes of origin, are far more difficult to find because millions of SNPs must currently be compared to thousands of trans...
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